Economics Notes: Economic modelling before clinical trials

Economic endpoints in clinical trials.

Economic endpoints are increasingly common in randomized clinical trials. As a relatively new addition to the field, methods of measuring and analyzing cost data are still evolving. These developments will be stimulated by the demands of the public for efficient and effective medical care, which will be based on the findings of clinical trials.

Evaluation of Clinical Trials

In a number of important clinical issues such as evaluation of the efficacy or effectiveness of therapeutic or preventive interventions as well as for comparing the harms of interventions, randomized controlled trials (RCTs) provide the highest levels of evidence, either directly or indirectly. It is obvious that critical appraisal of these studies to assess their validity and precision is of p...

Notes for Economics 200c*

Economic evaluations in cancer clinical trials

Authors: Stephen Goodall and Rosalie Viney Prepared: July 2011 SUMMARY • The aim of economic evaluation is to inform clinical and health system decision making and policy • Every time a decision is made about a new technology or treatment, a decision is also made about resource allocation • Economic evaluation is a formal and systematic comparison of the costs and benefits associated with two o...

Evaluation of new technologies for total hip replacement. Economic modelling and clinical trials.

Cost is a factor in the choice of prosthetic components in joint replacement. For a given performance, the least expensive components are the most cost-effective. When evaluating a new prosthesis with an unknown outcome, the use of an economic model allows estimation of potential cost-effectiveness. We used published data for the survival of cemented total hip replacements from Sweden, and cost...